Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study.

Giuseppe Pontillo Sirio Cocozza Roberta Lanzillo Camilla Russo Martina Di Stasi C Paolella E A Vola Chiara Criscuolo Pasquale Borrelli Giuseppe Palma Enrico Tedeschi Vincenzo Brescia Morra Andrea Elefante Arturo Brunetti

Published in: AJNR. American journal of neuroradiology (2018)

Our study confirms the diffuse involvement of deep gray matter in MS, demonstrating a different behavior between MS phenotypes, with subcortical GM atrophy mainly determined by global WM lesion burden in patients with relapsing-remitting MS, while local microstructural damage and susceptibility changes mainly accounted for the development of deep gray matter volume loss in patients with progressive MS.

Keyphrases

multiple sclerosis
white matter
mass spectrometry
ms ms
pain management
risk factors
chronic pain
systemic lupus erythematosus
contrast enhanced