Identification of EWSR1-NFATC2 fusion in simple bone cysts.

Yin Pun HungAdam S FischJulio A Diaz-PerezA John IafrateJochen K LennerzValentina NardiMiriam A BredellaKevin A RaskinSantiago A Lozano-CalderonAndrew E RosenbergG Petur Nielsen

Published in: Histopathology (2021)

More than 40% of simple bone cysts harbour genetic alterations confirming that they are neoplastic, investigation of EWSR1 and/or FUS rearrangement may help to distinguish simple bone cysts from mimics, and NFATC2 rearrangement is not pathognomonic of malignancy.

Keyphrases

bone mineral density
soft tissue
bone loss
bone regeneration
postmenopausal women
genome wide
gene expression
copy number
dna methylation