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Long-term outcomes and adaptive behavior in adult patients with Lennox-Gastaut syndrome.

Emanuele Cerulli IrelliAlessio PetrungaroGrazia M G PastorinoAdolfo MazzeoAlessandra MoranoSara CasciatoEmanuela SalatiFrancesca Felicia OpertoAnna T GiallonardoGiancarlo Di GennaroCarlo Di Bonaventura
Published in: Epilepsia open (2024)
This study examined adults with Lennox-Gastaut syndrome (LGS), a severe type of epilepsy, to understand their long-term abilities to perform daily tasks and adapt socially. We found that these adults have significant difficulties with daily living and social skills, although not all areas were equally affected. They performed somewhat better in communication, particularly in understanding others (receptive communication). Importantly, the younger the age at which LGS was diagnosed, the worse their outcomes were as adults. This study highlights the need for research and treatment approaches that focus not only on controlling seizures but also on improving daily life skills.
Keyphrases
  • physical activity
  • working memory
  • metabolic syndrome
  • adipose tissue
  • drug induced
  • replacement therapy