Risk of cardiovascular events according to the tricyclic antidepressant dosage in patients with chronic pain: a retrospective cohort study.

Hyunji Koo Seung-Hun You Sewon Park Kyeong Hye Jeong Nakyung Jeon Sun-Young Jung

Published in: European journal of clinical pharmacology (2022)

Close monitoring of patients on long-term, low-dose use of TCAs should be conducted to avoid an increase in the cumulative dose, which increases the risk of cardiovascular adverse events.

Keyphrases

cardiovascular events
chronic pain
low dose
coronary artery disease
end stage renal disease
ejection fraction
cardiovascular disease
major depressive disorder
prognostic factors
high dose
patient reported outcomes
bipolar disorder
patient reported