Genetic Polymorphisms Affecting Tacrolimus Metabolism and the Relationship to Post-Transplant Outcomes in Kidney Transplant Recipients.

Fang ChengQiang LiJinglin WangMin HuFang ZengZhendi WangYu Zhang

Published in: Pharmacogenomics and personalized medicine (2021)

Clinical factors, medication, and CYP-enzyme polymorphisms accounted for tacrolimus concentration variability in kidney transplantation recipients. Furthermore, higher tacrolimus concentrations were associated with higher diarrhea and PTDM risk.

Keyphrases

kidney transplantation
adverse drug
adipose tissue
weight loss
insulin resistance