Age and obesity-driven changes in the extracellular matrix of the primary tumor and metastatic site influence tumor invasion and metastatic outgrowth.
Sydney J ConnerJustinne R GuarinHannah B BorgesKenneth J SalhanyDiamond N MensahGrace A HamiltonGiang H LeMadeleine J OudinPublished in: bioRxiv : the preprint server for biology (2023)
Younger age and obesity increase the incidence and metastasis of triple-negative breast cancer. Our data suggest that changes in the breast, lung and liver ECM are driving some of these effects.