Protein Encapsulation of Experimental Anticancer Agents 5F 203 and Phortress: Towards Precision Drug Delivery.

Alastair F BreenDavid J ScurrMaria Letizia CassioliGeoffrey Wells Neil R ThomasJihong ZhangLyudmila Turyanska Tracey D Bradshaw

Published in: International journal of nanomedicine (2019)

Our results show enhanced potency and selectivity of AFt-encapsulated 5F 203 against carcinomas derived from breast, ovarian, renal, colorectal as well as gastric cancer models, and offer realistic prospects for potential refinement of tumour-targeting and treatment, and merit further in vivo investigations.

Keyphrases

drug delivery
cancer therapy
high grade
current status
combination therapy
binding protein
climate change
small molecule
drug release
replacement therapy
structural basis