PAC-Mediated AKI Protection Is Critically Mediated but Does Not Exclusively Depend on Cell-Derived Microvesicles.

Hassan Dihazi Katrin Schwarze Susann Patschan Gerhard Anton Müller Oliver Ritter M Zeisberg Daniel Patschan

Published in: International journal of nephrology (2021)

Together, our data show that PAC-mediated AKI protection substantially depends on the availability of cell-derived MV. However, since previous data showed improved AKI-protection by PACs after cell preconditioning with certain mediators (Ang-1 and -2, melatonin, BMP-5), mechanisms other than exclusively vesicle-dependent mechanisms must be involved in PAC-mediated AKI protection.

Keyphrases

acute kidney injury
big data
mesenchymal stem cells
single cell
machine learning
ischemia reperfusion injury
oxidative stress
deep learning
data analysis
bone regeneration