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Decreased prevalence of the Plasmodium falciparum Pfcrt K76T and Pfmdr1 and N86Y mutations post-chloroquine treatment withdrawal in Katete District, Eastern Zambia.

Mwenda C MulengaLungowe SitaliIlinca I CiubotariuMoonga B HawelaBusiku HamainzaJames ChipetaSungano Mharakurwa
Published in: Malaria journal (2021)
This study shows that there was a complete recovery of chloroquine-sensitive parasites by 2016 in Katete District, Eastern Zambia, 13 years following the withdrawal of CQ in the country. These findings add to the body of evidence for a fitness cost in CQ-resistant P. falciparum in Zambia and elsewhere. Further studies are recommended to monitor resistance countrywide and explore the feasibility of integration of the former best anti-malarial in combination therapy in the future.
Keyphrases
  • plasmodium falciparum
  • combination therapy
  • south africa
  • body composition
  • physical activity
  • risk factors
  • smoking cessation