Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma.
Angel C Y MakMarquitta J WhiteWalter L EckalbarZachary Alfano SzpiechSam S OhMaria Pino-YanesDonglei HuPagé GoddardScott HuntsmanJoshua GalanterAnn Chen WuBlanca E HimesSoren GermerJulia M VogelKaren L BuntingCeleste EngSandra SalazarKevin L KeysJennifer LibertoThomas J NucktonThomas A NguyenDara G TorgersonPui-Yan KwokAlbert M LevinJuan C CeledónErick FornoHakon HakonarsonPatrick M SleimanAmber DahlinKelan G TantisiraScott T WeissDenise SerebriskyEmerita Brigino-BuenaventuraHarold J FarberKelley MeadeMichael A LenoirPedro C AvilaSaunak SenShannon M ThyneWilliam Rodriguez-CintronCheryl A WinklerAndrés Moreno-EstradaKarla SandovalJose R Rodriguez-SantanaRajesh KumarL Keoki WilliamsNadav AhituvElad ZivMax A SeiboldRobert B DarnellNoah ZaitlenRyan D HernandezEsteban G Burchardnull nullPublished in: American journal of respiratory and critical care medicine (2019)
The lack of minority data, despite a collaboration of eight universities and 13 individual laboratories, highlights the urgent need for a dedicated national effort to prioritize diversity in research. Our study expands the understanding of pharmacogenetic analyses in racially/ethnically diverse populations and advances the foundation for precision medicine in at-risk and understudied minority populations.