Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux.

Dong-Lin YangYa-Jun ZhangLiu-Jun HeChun-Sheng HuLi-Xia GaoJiu-Hong HuangYan TangJie LuoDian-Yong TangZhong-Zhu Chen

Published in: Biological research (2021)

Taken together, our data demonstrated that T-96 is a novel modulator of ER stress and autophagy, and has potential therapeutic applications against CaP in the clinic.

Keyphrases

cell death
cell cycle arrest
endoplasmic reticulum stress
electronic health record
signaling pathway
primary care
oxidative stress
big data
dna damage
pi k akt
reactive oxygen species
deep learning