A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy.
Michael WiererJulia WernerJana WobstAdnan KastratiGanildo CepeleRédouane AherrahrouHendrik B SagerJeanette ErdmannMartin DichgansVeit FlockerziMete CivelekAlexander DietrichMatthias MannHeribert SchunkertThorsten KesslerPublished in: European heart journal (2021)
Our study provides a proteomic atlas of the healthy and injured arterial wall that can be used to define novel factors for therapeutic targeting. We present TRPC6 as an actionable target to prevent neointima formation secondary to vascular injury and stent implantation.