Echiumin E, an Aryl Dihydronaphthalene Lignan from the Australian Invasive Plant Paterson's Curse ( Echium plantagineum ).
Ju JinDarren C HollandAnthony R CarrollMatthew ZunkPublished in: Journal of natural products (2022)
A new aryl dihydronaphthalene lignan, echiumin E ( 1 ), and four known compounds, echiumin A, globoidnan A, (-)-rabdosiin, and rosmarinic acid ( 2 - 5 ), were isolated from the Australian invasive plant Echium plantagineum (Paterson's curse) for the first time. Echiumin E ( 1 ) was characterized by 1D/2D NMR spectroscopy and MS spectrometry, with its absolute configuration assigned through comparison of experimental and TDDFT-calculated ECD data. Echiumin E ( 1 ) along with compounds 3 - 5 were screened in vitro against three cancer cell lines (SH-SY5Y, HeLa, and PC-3) and a prostate stromal (normal) cell line (WPMY-1) using a resazurin reduction assay. Echiumin E ( 1 ) was found to be active toward HeLa cells (IC 50 0.21 μM).
Keyphrases
- cell cycle arrest
- cell death
- induced apoptosis
- pi k akt
- prostate cancer
- papillary thyroid
- mass spectrometry
- multiple sclerosis
- bone marrow
- high resolution
- high throughput
- ms ms
- squamous cell
- electronic health record
- big data
- signaling pathway
- endoplasmic reticulum stress
- squamous cell carcinoma
- machine learning
- gas chromatography
- liquid chromatography
- deep learning