Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia.

Tatsunori MaekawaToshikuni SasaokaSadahiro AzumaTakafumi IchikawaHeather L MelroseMatthew J FarrerFumiya Obata

Published in: BMC neuroscience (2016)

LRRK2 negatively regulates the clearance of αSYN accompanied by down-regulation of the endocytosis pathway. Our findings reveal a new functional role of LRRK2 in microglia and offer a new insight into the mechanism of PD pathogenesis.

Keyphrases

inflammatory response
neuropathic pain
single cell
protein kinase
gene expression
spinal cord injury
spinal cord