Increased markers of cardiac vagal activity in leucine-rich repeat kinase 2-associated Parkinson's disease.

Claudia Carricarte NaranjoConnie MarrasNaomi P VisanjiDavid J CornforthLazaro Sanchez-RodriguezBirgitt SchüleSamuel M GoldmanMario EstévezPhyllis K SteinAnthony E LangHerbert F JelinekAndrés Machado

Published in: Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2019)

Increased beat-to-beat HRV in LRRK2 G2019S mutation carriers compared with controls and idiopathic PD patients may indicate augmented cardiac autonomic cholinergic activity, suggesting early impairment of central vagal feedback loops in LRRK2-associated PD.

Keyphrases

heart rate
end stage renal disease
left ventricular
ejection fraction
chronic kidney disease
prognostic factors
patient reported outcomes