Effect of Isotretinoin on CYP2D6 and CYP3A Activity in Patients with Severe Acne.

Yuqian ZhaoJay C VaryAprajita S YadavLindsay C CzubaSara ShumJeffrey LaFranceWeize HuangNina IsoherranenMary F Hebert

Published in: British journal of clinical pharmacology (2023)

Administration of isotretinoin did not significantly reduce CYP2D6 activity in extensive metabolizers, suggesting that the predicted downregulation of CYP2D6 based on in vitro data does not translate into humans. We observed a modest increase in CYP3A activity (predominantly CYP3A4) with isotretinoin treatment. The data also suggest dextrorphan glucuronidation is increased following isotretinoin administration.

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