Does Familial Mediterranean Fever Provoke Atherosclerosis in Children? Evaluation of Arterial Stiffness and Serum Endocan Levels.
Serkan TürkuçarKaan YıldızTuncay KümeCeyhun AçarıHatice Adıgüzel DundarBalahan MakayMustafa KırErbil ÜnsalPublished in: Clinical rheumatology (2021)
Good disease control could be preventive for atherosclerosis in children with FMF. On the other hand, screening for cardiovascular diseases is essential, particularly for uncontrolled cases. Distribution of MEFV gene mutations KEY POINTS: • Exaggerated inflammation is the prominent feature of FMF attacks; moreover, it is shown that subclinical inflammation might also continue in attack-free periods. • Chronic inflammation contributes to atherosclerotic process in almost all stages by activating endothelial cells, producing reactive oxygen species, and accelerating foam cell and atherosclerotic plaque formations. • However, the results of this study showed that there was no difference in terms of atherosclerotic markers such as serum endocan levels and arterial stiffness parameters between pediatric FMF patients and healthy peers. • Good disease control in pediatric FMF patients may prevent early atherosclerotic changes during childhood, which then may lead a probable decreased risk of subsequent CVD in adulthood.
Keyphrases
- end stage renal disease
- cardiovascular disease
- oxidative stress
- ejection fraction
- endothelial cells
- chronic kidney disease
- newly diagnosed
- blood pressure
- young adults
- reactive oxygen species
- coronary artery disease
- type diabetes
- machine learning
- stem cells
- signaling pathway
- deep learning
- metabolic syndrome
- bone marrow