During the COVID-19 pandemic, we are fighting not only the novel coronavirus, but also the "infodemic" induced by the pandemic. Therefore, it is urgent to explore approaches for enhancing individual immunity against science-related misinformation. We conducted a cross-sectional study to examine the relationship between public engagement with science (PES) and scientific information literacy (SIL) during the COVID-19 pandemic from college students (N = 8075) in China. The results showed that there was a significant difference between attitudes toward and activities of PES. More importantly, both PES activities and PES attitudes were found positively associated with SIL, especially the PES attitudes. The empirical study is significant in demonstrating the predictive effect of PES on individual ability to recognize science-related misinformation, which is crucial for mitigating harm from the "infodemic." Our study indicated that other than a science communication model in order to restore public trust in science, PES is promising to be incorporated into informal science education to facilitate individual SIL.