Arsenic Exposure, Blood DNA Methylation, and Cardiovascular Disease.

Arce Domingo-RellosoKiran MakhaniAngela L Riffo-Campos Maria Tellez-PlazaKathleen Oros KleinPooja SubediJinying ZhaoKatherine A MoonAnne K Bozack Karin Haack Walter Goessler Jason G UmansLyle G BestYing ZhangMiguel Herreros-Martinez Ronald A Glabonjat Kathrin Schilling Marta Galvez-FernandezJack W KentTiffany R SanchezKent D Taylor W Craig JohnsonPeter DurdaRussell P Tracy Jerome I Rotter Stephen S RichDavid Van Den BergSilva KaselaTuuli LappalainenRamachandran S Vasan Roby JoehanesBarbara V HowardDaniel LevyKurt LohmanYongmei LiuM Daniele FallinShelley A ColeKoren K MannAna Navas-Acien

Published in: Circulation research (2022)

Differential DNA methylation might be part of the biological link between arsenic and CVD. The gene functions suggest that diabetes might represent a relevant mechanism for arsenic-related cardiovascular risk in populations with a high burden of diabetes.

Keyphrases

cardiovascular disease
dna methylation
drinking water
genome wide
type diabetes
heavy metals
gene expression
glycemic control
copy number
cardiovascular events
cardiovascular risk factors
risk assessment
skeletal muscle
adipose tissue
transcription factor
weight loss
coronary artery disease