The USH3A causative gene clarin1 functions in Müller glia to maintain retinal photoreceptors.
Hannah J T NonarathSamantha L SimpsonTricia L SlobodianukRoss F ColleryAstra DinculescuBrian A LinkPublished in: bioRxiv : the preprint server for biology (2024)
mutant zebrafish. We also highlight that the dosage of Clrn1 in Müller glia is critical for maintaining proper photoreceptor function. These findings demonstrate the key contribution of Müller glia to USH pathology and can guide strategies for gene-replacement therapies.