Microparticles from stored red blood cells enhance procoagulant and proinflammatory activity.
Dania FischerJulian BüssowPatrick MeybohmChristian Friedrich WeberKai ZacharowskiAnja UrbschatMarkus Matthias MüllerCarla JenneweinPublished in: Transfusion (2017)
Our results suggest that RMPs trigger coagulation through TF signaling, induce the secretion of proinflammatory cytokines, and induce cell-cell interaction between platelets and neutrophils. Thus, under certain conditions, RMPs could play a role in post-transfusion complications through these mechanisms.