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Image-based deep learning identifies glioblastoma risk groups with genomic and transcriptomic heterogeneity: a multi-center study.

Jing YanQiuchang SunXiangliang TanChaofeng LiangHongmin BaiWenchao DuanTianhao MuYang GuoYuning QiuWeiwei WangQiaoli YaoDongling PeiYuanshen ZhaoDanni LiuJingxian DuanShifu ChenChen SunWenqing WangZhen LiuXuanke HongXiangxiang WangYu GuoYikai XuXianzhi LiuJingliang ChengZhi-Cheng LiZhenyu Zhang
Published in: European radiology (2022)
• MRI-based deep learning imaging signature (DLIS) stratifies GBM into risk groups with distinct molecular characteristics. • DLIS is associated with P53, RB, and RTK pathways and del_CDNK2A mutation. • The prognostic value of DLIS-correlated pathway genes is externally demonstrated.
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