An MRI evaluation of white matter involvement in paradigmatic forms of spastic ataxia: results from the multi-center PROSPAX study.
Alessandra ScaravilliIlaria GabusiGaia MariMatteo BattocchioSara BosticardoSimona SchiaviBenjamin BenderChristoph KesslerBernard BraisRoberta La PianaBart P van de WarrenburgMirco CosottiniDagmar Timmannnull nullAlessandro DaducciRebecca SchüleMatthis SynofzikFilippo Maria SantorelliSirio CocozzaPublished in: Journal of neurology (2024)
In ARSACS, but not SPG7 patients, we observed a complex and multi-faced involvement of brain WM, with a clinically meaningful widespread loss of axonal and dendritic integrity, secondary demyelination and, overall, a reduction in cellularity and volume.
Keyphrases
- white matter
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- multiple sclerosis
- spinal cord injury
- peritoneal dialysis
- prognostic factors
- contrast enhanced
- magnetic resonance
- patient reported outcomes
- resting state
- brain injury
- blood brain barrier
- cerebral palsy
- diffusion weighted imaging
- upper limb
- botulinum toxin