Engineering of Naproxen Loaded Polymer Hybrid Enteric Microspheres for Modified Release Tablets: Development, Characterization, in silico Modelling and in vivo Evaluation.
Hajra Afeera HameedShahzeb KhanMuhammad ShahidRiaz UllahAhmed BariSyed Saeed AliZahid HussainMuhammad SohailShafi Ullah KhanThet-Thet HtarPublished in: Drug design, development and therapy (2020)
The current study concludes that developing NP loaded PHE-Ms based tablets could effectively reduce GIT consequences with restored therapeutic effects. The modified release pattern could improve the dissolution rate and enhancement of oral bioavailability. The MM study strengthens the polymer-drug relationship in microspheres.