CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity.

Sasha GuptaMilos SimicSharon A SaganChanelle ShepherdJason DueckerRaymond A SobelRavi DandekarGregory F WuWesley WuJohn E PakStephen L HauserWendell LimMichael R WilsonScott S Zamvil

Published in: Neurology(R) neuroimmunology & neuroinflammation (2023)

In contrast to previous data showing that anti-CD19 CAR-T cell treatment exacerbated EAE, we observed that anti-CD19 CAR-T cells ameliorated EAE. In addition, anti-CD19 CAR-T cells thoroughly depleted B cells in peripheral tissues and in the CNS. However, the clinical benefit occurred independently of antigen specificity or B-cell depletion.

Keyphrases

single cell
cell therapy
nk cells
magnetic resonance
gene expression
stem cells
computed tomography
cerebrospinal fluid