Regional analysis and genetic association of nigrostriatal degeneration in Lewy body disease.

Koji KasanukiMichael G HeckmanNancy N DiehlMelissa E MurrayShunsuke KogaAlexandra SotoOwen A RossGourisankar Ghosh

Published in: Movement disorders : official journal of the Movement Disorder Society (2017)

The results confirm regional differences in putaminal dopaminergic degeneration and vulnerability of nigrostriatal pathway in Lewy body disorders with parkinsonism. The lack of association with PD genetic risk variants suggests that they may not be associated with quantitative endophenotypes of nigrostriatal degeneration, but more likely related to the risk of disease per se. © 2017 International Parkinson and Movement Disorder Society.

Keyphrases

parkinson disease
copy number
genome wide
climate change
high resolution
gene expression
deep brain stimulation
mass spectrometry