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Comparison of stool samples and rectal swabs with and without pre-enrichment for the detection of third-generation cephalosporin-resistant Enterobacterales (3GCREB).

Tarek JazmatiAxel G HamprechtNathalie Jazmati
Published in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2021)
To establish the optimal detection of third-generation cephalosporin-resistant Enterobacterales (3GCREB), the performance of four different screening methods has been investigated: stool samples without (A) and with (B) pre-enrichment and rectal swabs without (C) and with (D) pre-enrichment were contrasted. Pre-enrichment approaches (B and D) increased the detection of 3GCREB carriers by 29.4% (20/68 3GCREB carriers only found using pre-enrichment, p < 0.0001) compared to direct plating approaches (A and C). Moreover, the study demonstrates a minor advantage of stool samples in contrast to rectal swabs in both cases (with and without pre-enrichment). Registration number: DRKS00022520, 24 July 2020.
Keyphrases
  • rectal cancer
  • loop mediated isothermal amplification
  • magnetic resonance imaging
  • computed tomography
  • label free
  • real time pcr
  • gram negative
  • mass spectrometry