Specific populations of urinary extracellular vesicles and proteins differentiate type 1 primary hyperoxaluria patients without and with nephrocalcinosis or kidney stones.
Muthuvel JayachandranStanislav V YuzhakovSanjay KumarNicholas B LarsonFelicity T EndersDawn S MillinerAndrew D RuleJohn C LieskePublished in: Orphanet journal of rare diseases (2020)
These results imply activation of distinct renal tubular and interstitial cell populations and processes associated with KS and NC, and suggest specific populations of urinary EVs and proteins are potential biomarkers to assess the pathogenic mechanisms between KS versus NC among PH1 patients.