An ESIPT-induced NIR fluorescent probe to visualize mitochondrial sulfur dioxide during oxidative stress in vivo.
Haixian RenFangjun HuoXia WuXiaogang LiuCaixia YinPublished in: Chemical communications (Cambridge, England) (2021)
Based on the change in electron distribution of the benzopyrylium unit before and after sulfite addition, a 2-(2'-hydroxyphenyl)benzothiazole (HBT)-based fluorophore generated the excited state intramolecular proton transfer (ESIPT) process with a near-infrared enhanced emission at 836 nm and a large Stokes shift (286 nm). The probe was applied to image SO2 derivatives in cells and mice. Our data will provide new ideas for the development of ESIPT-based fluorescence probe with longer wavelength emission.
Keyphrases
- fluorescent probe
- living cells
- oxidative stress
- induced apoptosis
- diabetic rats
- photodynamic therapy
- energy transfer
- cell cycle arrest
- electron transfer
- high glucose
- electronic health record
- dna damage
- ischemia reperfusion injury
- deep learning
- single molecule
- endoplasmic reticulum stress
- signaling pathway
- big data
- drug induced
- quantum dots
- type diabetes
- light emitting
- cell death
- cell proliferation
- adipose tissue
- pi k akt
- structure activity relationship
- data analysis
- electron microscopy
- endothelial cells
- heat shock
- wild type