Food allergy in children is associated with Vitamin D deficiency: a case-control study.

The association between Food allergy (FA), Vitamin D deficiency (VDD) and Vitamin D binding protein (VDBP) is of special interest (1). A previous study has shown that low serum Vitamin D levels were associated with food allergy, particularly amongst infants with specific VDBP gene polymorphisms (2). In addition, infants of Australian-born parents with inadequate vitamin D levels were more likely to be food allergic than were those with adequate vitamin D levels (3). In the United States, a significant association between VDD and the sensitisation to food allergens was detected (1). On the contrary, a recent systematic review could not detect any difference in Vitamin D levels in children with or without FA, indicating that, the relationship between FA and Vitamin D remains controversial (4).