Astragaloside IV Protects from PM2.5-Induced Lung Injury by Regulating Autophagy via Inhibition of PI3K/Akt/mTOR Signaling in vivo and in vitro.

Caixia PeiFei WangDemei Huang Shihua ShiXiaomin WangYilan WangShuiqin LiYongcan Wu Zhenxing Wang

Published in: Journal of inflammation research (2021)

Our data indicated that AS-IV protects from PM2.5-induced lung injury in vivo and in vitro by inhibiting the PI3K/Akt/mTOR pathway to regulate autophagy and inflammation.

Keyphrases

oxidative stress
diabetic rats
signaling pathway
high glucose
particulate matter
cell death
air pollution
drug induced
endothelial cells
big data
risk assessment
artificial intelligence