CELSR1 Risk Alleles in Familial Bicuspid Aortic Valve and Hypoplastic Left Heart Syndrome.
Jeanne L TheisTalha NiazRhianna S SundsbakZachary C FogartyWilliam R BamletDonald J HaglerTimothy M OlsonPublished in: Circulation. Genomic and precision medicine (2022)
is a susceptibility gene for familial BAV and HLHS, further implicating planar cell polarity pathway perturbation in congenital heart disease.
Keyphrases
- aortic valve
- congenital heart disease
- aortic stenosis
- transcatheter aortic valve replacement
- aortic valve replacement
- transcatheter aortic valve implantation
- early onset
- single cell
- heart failure
- copy number
- genome wide
- atrial fibrillation
- stem cells
- left ventricular
- genome wide identification
- mesenchymal stem cells
- dna methylation