Comparison of visceral adipose tissue DNA methylation and gene expression profiles in female adolescents with obesity.
Matthew D BarberioEvan P NadlerSamantha SevillaRosemary LuBrennan HarmonMonica J HubalPublished in: Diabetology & metabolic syndrome (2019)
Our analyses show obesity-related differences in DNA methylation and gene expression in visceral adipose tissue of adolescent females. Specifically, we identified methylation site/gene expression pairs differentially regulated and mapped these differences to pathways including PI3K/AKT signaling, suggesting that PI3K/AKT signaling pathway dysfunction in obesity may be driven in part by changes in DNA methylation.
Keyphrases
- pi k akt
- dna methylation
- insulin resistance
- gene expression
- signaling pathway
- adipose tissue
- genome wide
- metabolic syndrome
- high fat diet induced
- high fat diet
- cell cycle arrest
- cell proliferation
- young adults
- skeletal muscle
- type diabetes
- weight loss
- weight gain
- induced apoptosis
- epithelial mesenchymal transition
- oxidative stress
- copy number
- physical activity
- transcription factor
- mental health