Association of Drug Metabolic Enzyme Genetic Polymorphisms and Adverse Drug Reactions in Patients Receiving Rifapentine and Isoniazid Therapy for Latent Tuberculosis.
Ya-Yen YuShih-Ming TsaoWen-Ta YangWei-Chang HuangChing-Hsiung LinWei-Wen ChenChiao-Wen LinHui-Ling ChiouYi-Wen HuangPublished in: International journal of environmental research and public health (2019)
Weekly rifapentine and isoniazid therapy (3HP) is the most frequent treatment for latent tuberculosis infection (LTBI). However, the association between major adverse drug reactions (ADRs) and drug metabolic enzyme single-nucleotide polymorphisms (SNPs) remains unclear. In this study, 377 participants who received the 3HP regimen were recruited and examined for genotyping of CYP5A6, CYP2B6, CYP2C19, CYP2E1, and NAT2 SNPs. In our study, 184 participants (48.4%) developed ADRs. Moreover, CYP2C19 rs4986893 (TT vs. CC+CT, odds ratio [OR] [95% CI]: 2.231 [1.015-4.906]), CYP2E1 rs2070676 (CC vs. CG+GG, OR [95% CI]: 1.563 [1.022-2.389]), and CYP2E1 rs2515641 (CC vs. CT+TT, OR [95% CI]: 1.903 [1.250-2.898]) were associated with ADR development. In conclusion, CYP2C19 and CYP2E1 SNPs may provide useful information regarding ADRs in LTBI patients receiving the 3HP regimen.
Keyphrases
- adverse drug
- mycobacterium tuberculosis
- electronic health record
- genome wide
- emergency department
- drug induced
- computed tomography
- magnetic resonance imaging
- healthcare
- contrast enhanced
- high throughput
- dual energy
- positron emission tomography
- hiv infected
- single cell
- combination therapy
- antiretroviral therapy
- smoking cessation