Lipopolysaccharide-induced maternal inflammation induces direct placental injury without alteration in placental blood flow and induces a secondary fetal intestinal injury that persists into adulthood.
Erin M FrickeTimothy G ElginHuiyu GongJeff ReeseKatherine N Gibson-CorleyRobert M WeissKathy ZimmermanNoelle C BowdlerKaren M KalanteraDavid A MillsMark A UnderwoodSteven J McElroyPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)
Lipopolysaccharide causes a maternal inflammatory response that is mirrored in the placenta. Placental histology demonstrates structural changes; however, placental blood flow is preserved. LPS also induces an indirect intestinal injury in the offspring that lasts beyond the neonatal period.