Interferon activated gene 204 protects against bone loss in experimental periodontitis.

Karen V SwansonMustafa GirnaryTomaz AlvesJenny Py TingKimon DivarisJim BeckCarolina Maschietto PucinelliRaquel Assed Bezerra da SilvaDilek UyanJustin E WilsonWilliam T SeamanJennifer Webster-CyriaqueNishma ViasYizu JiaoLloyd CantleyArnaud MarlierRoland R ArnoldJulie Teresa Marchesan

Published in: Journal of periodontology (2022)

These findings support IFI16's role as a novel regulator of inflammatory cell trafficking to the periodontium that protects against bone loss and offers potential targets for the development of new periodontal disease biomarkers and therapeutics.

Keyphrases

bone loss
single cell
cell therapy
genome wide
oxidative stress
small molecule
transcription factor
dendritic cells
copy number
stem cells
genome wide identification
human health
risk assessment
bone marrow