25-Hydroxyvitamin D3 -enhanced PTPN2 positively regulates periodontal inflammation through the JAK/STAT pathway in human oral keratinocytes and a mouse model of type 2 diabetes mellitus.

P ZhangW ZhangD ZhangM WangR AprecioN JiO MohamedY LiY DingQi Wang

Published in: Journal of periodontal research (2018)

PTPN2 contributed to a decrease in periodontal inflammation in type 2 diabetes mellitus via dephosphorylate protein substrates in the JAK1/STAT3 signaling pathway after 25VD3 treatment in human oral keratinocytes and a mouse model of type 2 diabetes mellitus. A thorough understanding of PTPN2 and its involvement in inhibiting inflammation might provide alternative therapeutic approaches for the pathogenesis and treatment of diabetes mellitus-associated periodontitis.

Keyphrases

mouse model
signaling pathway
oxidative stress
endothelial cells
induced pluripotent stem cells
type diabetes
adipose tissue
insulin resistance
metabolic syndrome
induced apoptosis
glycemic control
binding protein