Differential association of cortical, subcortical and spinal cord damage with multiple sclerosis disability milestones: A multiparametric MRI study.

Milagros Hidalgo de la CruzPaola ValsasinaAlessandro MeaniAntonio GalloClaudio GobbiAlvino BiseccoGioacchino TedeschiChiara Zecca Maria Assunta RoccaMassimo Filippi

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2021)

Brain lesion burden, cortical and thalamic atrophy were the main determinants of EDSS = 3.0 and 4.0, while cord damage played a major contribution to EDSS = 6.0.

Keyphrases

multiple sclerosis
white matter
spinal cord
oxidative stress
magnetic resonance imaging
spinal cord injury
contrast enhanced
deep brain stimulation
resting state
neuropathic pain
risk factors
computed tomography
magnetic resonance
diffusion weighted imaging
functional connectivity