Three new dihydrochalcones from the leaves of Artocarpus sericicarpus Jarrett and their activity against Plasmodium falciparum .

Three new dihydrochalcones: artoserichalcone A-C ( 1-3 ), were isolated from the leaves of Artocarpus sericicarpus . The structures of compounds were determined based on NMR spectrum ( 1 H, 13 C, and 2D) and HRESIMS spectroscopic analysis. Compounds ( 1 ) and ( 3 ) showed active antimalarial activity with IC 50 values of 16.90 and 13.56 µM, respectively. Meanwhile, compound ( 2 ) with an IC 50 value of 63.01 µM was categorised as a moderate antimalarial substance. The cytotoxicity against Huh7, HepG2, BHK-21, and Vero cells showed that compounds ( 1-3 ) with CC 50 values > 20 µg/mL could be considered non-cytotoxic. Compounds ( 1-3 ) exhibited antimalarial activity against Plasmodium falciparum and non-toxic as an antimalarial agent.