COlchicine to Prevent PeriprocEdural Myocardial Injury in Percutaneous Coronary Intervention (COPE-PCI): Coronary Microvascular Physiology Pilot Substudy.
Justin ColeNay HtunRobert LewMark FreilichStephen QuinnJamie LaylandPublished in: Journal of interventional cardiology (2022)
In this pilot randomized substudy, colchicine given 6 to 24 hours before PCI did not statistically impact the post-PCI CMVD definition used in this study, yet it did improve post-PCI RRR and CFR measurements, with less procedure-related troponin release and less inflammation.
Keyphrases
- percutaneous coronary intervention
- coronary artery disease
- st segment elevation myocardial infarction
- st elevation myocardial infarction
- acute myocardial infarction
- antiplatelet therapy
- acute coronary syndrome
- coronary artery bypass grafting
- atrial fibrillation
- coronary artery bypass
- oxidative stress
- study protocol
- open label
- double blind
- coronary artery
- placebo controlled
- left ventricular
- clinical trial
- aortic stenosis