Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor.

Małgorzata MaksymowiczMarta MiączyńskaMagdalena Banach-Orłowska

Published in: Cell communication and signaling : CCS (2020)

Our work shows that the impairment of clathrin- and dynamin-dependent internalization amplifies a cellular response to LTβR stimulation. We postulate that receptor internalization restricts responsiveness of the cell to subthreshold stimuli. Video Abstract.

Keyphrases

single cell
cell therapy
oxidative stress
lps induced
nuclear factor
mesenchymal stem cells
toll like receptor