Nickel-Promoted Recognition of Long DNA Sites by Designed Peptide Derivatives.
Jéssica RodríguezJesús MosqueraM Eugenio VázquezJosé L MascareñasPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2016)
We describe the synthesis of designed peptidic modules that self-assemble in specific DNA sequences of 12 base pairs in the presence of Ni(II) salts. The modules consist of modified fragments of transcription factors that have been appropriately engineered to include metal-chelating His and bipyridine ligands.