Bone Marrow-Derived RIPK3 Mediates Kidney Inflammation in Acute Kidney Injury.

Diego Martin-SanchezJuan Guerrero-MauvecinMiguel Fontecha-BarriusoNerea Mendez-BarberoMaria Laura SaizAna M Lopez-DiazMaria D Sanchez-NiñoSusana CarrascoPablo Cannata-OrtizMarta Ruiz-OrtegaAlberto Ortiz Arduan Ana Belen Sanz

Published in: Journal of the American Society of Nephrology : JASN (2022)

RIPK3 mediates kidney inflammation independently from tubular cell death. Specific targeting of bone marrow-derived RIPK3 may limit kidney inflammation without the potential adverse effects of systemic RIPK3 targeting.

Keyphrases

oxidative stress
acute kidney injury
cell death
mesenchymal stem cells
cancer therapy
cardiac surgery
cell proliferation
climate change
cell cycle arrest
drug induced