Clostridium difficile-related postinfectious IBS: a case of enteroglial microbiological stalking and/or the solution of a conundrum?
Gabrio BassottiLara MacchioniLanfranco CorazziPierfrancesco MarconiKatia FettucciariPublished in: Cellular and molecular life sciences : CMLS (2017)
Post-infectious irritable bowel syndrome is a well-defined pathological entity that develops in about one-third of subjects after an acute infection (bacterial, viral) or parasitic infestation. Only recently it has been documented that an high incidence of post-infectious irritable bowel syndrome occurs after Clostridium difficile infection. However, until now it is not known why in some patients recovered from this infection the gastrointestinal disturbances persist for months or years. Based on our in vitro studies on enteric glial cells exposed to the effects of C. difficile toxin B, we hypothesize that persistence of symptoms up to the development of irritable bowel syndrome might be due to a disturbance/impairment of the correct functions of the enteroglial intestinal network.
Keyphrases
- irritable bowel syndrome
- clostridium difficile
- end stage renal disease
- chronic kidney disease
- ejection fraction
- induced apoptosis
- escherichia coli
- newly diagnosed
- liver failure
- prognostic factors
- sars cov
- peritoneal dialysis
- cell cycle arrest
- oxidative stress
- drug induced
- patient reported outcomes
- physical activity
- hepatitis b virus
- spinal cord
- cell proliferation
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- aortic dissection