North American population-based validation of the National Comprehensive Cancer Network Practice Guideline Recommendations for locoregional lymph node and bone imaging in prostate cancer patients.
Felix PreisserElio MazzoneSebastiano NazzaniMichele MarchioniMarco BandiniZhe TianFred SaadDenis SoulièresShahrokh F ShariatFrancesco MontorsiHartwig HulandMarkus GraefenDerya TilkiPierre I KarakiewiczPublished in: British journal of cancer (2018)
The NCCN recommendations for locoregional LNM miss few patients with clinical LNM (0.3-0.4%) and provide a virtually perfect NPV of 99.5%. Also, the recommendations for bone scan miss a marginal number of patients with established bone metastases (0.14%) and yield a virtually perfect NPV of 99.8%.