In vitro proof of concept studies of radiotoxicity from Auger electron-emitter thallium-201.

Katarzyna M OsytekPhilip J BlowerInes M CostaGareth E SmithVincenzo AbbateSamantha Y A Terry

Published in: EJNMMI research (2021)

201Tl reduces clonogenic survival and increases nuclear DNA damage only when internalized. These findings justify further development and evaluation of 201Tl therapeutic radiopharmaceuticals.

Keyphrases

dna damage
oxidative stress
dna repair
case control
free survival
electron microscopy