Quantitative MRI Measures and Cognitive Function in People With Drug-Resistant Juvenile Myoclonic Epilepsy.
Bernardo Crespo PimentelGiorgi KuchukhidzeFenglai XiaoLorenzo CaciagliJulia HoeflerLucas RainerMartin KronbichlerChristian VollmarJohn Sidney DuncanEugen TrinkaMatthias J KoeppBritta WandschneiderPublished in: Neurology (2024)
We identified a developmental phenotype in individuals with drug-resistant JME characterized by changes in cortical surface area and folding complexity, the extent of which correlates with executive dysfunction. No association was observed between cortical thickness and disease severity. Our findings support a neurodevelopmental basis for drug resistance and cognitive impairment in JME.
Keyphrases
- drug resistant
- cognitive impairment
- multidrug resistant
- acinetobacter baumannii
- magnetic resonance imaging
- contrast enhanced
- single molecule
- optical coherence tomography
- oxidative stress
- high resolution
- working memory
- molecular dynamics simulations
- diffusion weighted imaging
- computed tomography
- magnetic resonance
- cystic fibrosis