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Pd-Catalyzed Asymmetric Dearomative Arylation of Indoles via a Desymmetrization Strategy.

Yu-Han NieMasaaki KomatsudaPing YangChao ZhengJunichiro YamaguchiShu-Li You
Published in: Organic letters (2022)
Pd-catalyzed asymmetric dearomative arylation of C3-substituted indoles is realized via a desymmetrization strategy. A BINOL-derived chiral phosphoramidite ligand is found to be highly efficient for the stereoselective control in this reaction. This method provides a convenient synthesis of spiroindolenines bearing two stereogenic centers in good yields (up to 98%) with excellent diastereo- and enantioselectivities (up to >20:1 dr and 97% ee), which could also be applied in asymmetric dearomative arylation of the simple C3-tethered indoles.
Keyphrases
  • highly efficient
  • room temperature
  • solid state
  • molecular docking
  • editorial comment