Association of intestinal and systemic inflammatory biomarkers with immune reconstitution in HIV+ patients on ART.
Mariana Del Rocio Ruiz-BriseñoJudith Carolina De Arcos-JiménezSarah Ratkovich-GonzálezKarina Sánchez-ReyesLuz A González-HernándezJaime F Andrade-VillanuevaMonserrat Alvarez-ZavalaPublished in: Journal of inflammation (London, England) (2020)
Our data suggests that despite the virologic control, HIV+ patients under treatment with deficient immune reconstitution showed elevation of both innate and T-cells immune activation, as well as intestinal and systemic inflammation. However, some patients with CD4+ T-cells count above 350 cells/μL also presented these alterations. Future studies are necessary to evaluate the dynamics of multiple systemic and intestinal biomarkers in diverse types of HIV+ patients, as such as their clinical impact.
Keyphrases
- end stage renal disease
- antiretroviral therapy
- hiv infected
- ejection fraction
- newly diagnosed
- chronic kidney disease
- human immunodeficiency virus
- hiv positive
- prognostic factors
- peritoneal dialysis
- machine learning
- hiv aids
- hiv testing
- oxidative stress
- cell death
- signaling pathway
- induced apoptosis
- men who have sex with men
- smoking cessation
- endoplasmic reticulum stress