Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription JieZe-1 in protecting against HSV-2 infection.

Tong LiuQingqing ShaoWenjia WangYonggui MaTianli LiuXiming JinJianguo FangGuangying HuangYunus Emre Kundakci

Published in: Pharmaceutical biology (2022)

The present study demonstrated that JZ-1 protected mice from HSV-2 infection and inhibit the caspase-1-dependent pyroptosis in GH mice. It is of significance for the second development of JZ-1 and the exploration of new drugs.

Keyphrases

high fat diet induced
herpes simplex virus
cell death
type diabetes
wild type
insulin resistance
induced apoptosis
adipose tissue
metabolic syndrome
oxidative stress
skeletal muscle
signaling pathway
network analysis