Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription JieZe-1 in protecting against HSV-2 infection.
Tong LiuQingqing ShaoWenjia WangYonggui MaTianli LiuXiming JinJianguo FangGuangying HuangYunus Emre KundakciPublished in: Pharmaceutical biology (2022)
The present study demonstrated that JZ-1 protected mice from HSV-2 infection and inhibit the caspase-1-dependent pyroptosis in GH mice. It is of significance for the second development of JZ-1 and the exploration of new drugs.